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[email protected] 617-919-4457 Title: Transplantation of Autologously Derived Mitochondria for Protection against Ischemia-Reperfusion Injury following Ischemia Due to ECMO Description: A robust therapeutic intervention is proposed to ameliorate myocardial ischemia/ reperfusion injury and significantly decrease morbidity and mortality in patients requiring extracorporeal membrane oxygenation (ECMO), by direct injection of autogeneic mitochondria into the ischemic [email protected] 617-919-4457 Title: Mesoblast Stem Cell Therapy for Patients with Single Ventricle and Borderline Left Ventricle Description: This is a randomized trial for those patients with hypoplastic left heart syndrome (HLHS), unbalanced atrioventricular canal (u AVC), or borderline left heart undergoing LV recruitment or future plans for [email protected] 617-919-4457 Title: Determining the Natural and “Unnatural” History of Anomalous Aortic Origin of a Coronary Artery with an Interarterial Course (AAOCA): Establishing a Multi-Institutional Registry Description: A risk stratification model will be created utilizing a large, multi-institutional registry under the auspices of the Congenital Heart Surgeon Society (CHSS).The purpose of the study is to determine the outcome of surgical intervention versus observation in children and young adults with AAOCA.Eligible subjects will undergo one of the following one surgeries: VSD repair, To F repair or ASO. Ford MA, Gauvreau K, Mc Mullan DM, Almodovar MC, Cooper DS, Rycus PT, Thiagarajan R. Coronary Artery Aneurysms in Kawasaki Disease: Risk Factors for Progressive Disease and Adverse Cardiac Events in the US Population. Participants will receive open-label dexmedetomidine while in the operating room and up to 12 hours after surgery in the CICU. Factors Associated With Mortality in Neonates Requiring Extracorporeal Membrane Oxygenation for Cardiac Indications: Analysis of the Extracorporeal Life Support Organization Registry Data. [email protected] 617-919-4457 Title: Surgical Planning with 3-D Printed Cardiac Models in Patients with Malformations that Require Biventricular Repair Description: It is hypothesized that pre-op surgical planning via inspection of a 3-D printed cardiac model will reduce time spent inspecting the intracardiac anatomy, and thus also reduce OR time, reduce the incidence of residual lesions, and improve comfort and confidence levels of the surgeon.

[email protected] 617-355-4201 Title: Fontan Udenafil Exercise Longitudinal (FUEL) Assessment Trial Description: The purpose of this study is to find out if udenafil can improve or reduce decline in exercise ability of Fontan patients ages 12 to 19 years. Emani SM, Piekarski BL, Zurakowski D, Baird CA, Marshall AC, Lock JE, del Nido PJ. Concept of an expandable cardiac valve for surgical implantation in infants and children. Incidence and Predictors for Postoperative Thrombotic Complications in Children With Surgical and Nonsurgical Heart Disease. [email protected] 857-218-3847 Title: Data Fusion: A Sustainable, Scalable, Open Source Registry Advancing PVD Research Description: This multi-center, long-term study leverages and extends the existing Pediatric Pulmonary Hypertension Network (PPHNet) for large-scale registry and EHR-based research of patients with pulmonary hypertension.This virtual PH research repository aims to complement traditional data sources for epidemiological research, enabling superior collection of phenotype, outcomes, and therapeutic efficacy data.Participants will receive therapy for up to 12 months. Enrollment goal: 25 Primary investigator: Christina Vander Pluym, MD Contact: Priscilla Cevallos: Priscila. Jenkins KJ, Koch Kupiec J, Owens PL, Romano PS, Geppert JJ, Gauvreau K.

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The goal is to design an algorithm using point-of-care monitoring that could be used to diagnose coagulopathies and to guide hemostatic therapies to alleviate morbidity and mortality in children undergoing cardiac surgery.

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